Use of Calcium Channel Blockers and Parkinson’s Disease

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Original Contribution Use of Calcium Channel Blockers and Parkinson’s Disease

Experimental evidence and case-control studies suggest that dihydropyridine calcium channel blockers (DiCCBs) may protect against Parkinson’s disease. The authors conducted a historical cohort study in Denmark to investigate the association between DiCCB use and risk of Parkinson’s disease (1998–2006). Individual-level data on filled drug prescriptions, diagnostic information, and covariates we...

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Use of calcium channel blockers in hypoxic lung disease.

COPD patients who are hypoxic develop pulmonary hypertension primarily because alveolar hypoxia induces muscular hypertrophy of pulmonary arteries. This muscular hypertrophy will regress in animals if they receive continuous oxygen therapy. Since many COPD patients refuse to use oxygen continuously, calcium channel blockers, which inhibit hypoxic pulmonary vasoconstriction, may be effective adj...

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Wound healing is a natural response to restore the injured tissue to normal. Wound healing is also complicated process involving different cellular, molecular and biochemical mechanisms and various types of cytokines and growth factors. Calcium channel blockers belong to cardiovascular medicine and administrated to treatment of hypertension, angina and cardiac arrhythmia because of vasodilatory...

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Effect of Calcium Channel Blockers on Intraocular Pressure in Rabbits

The objective of the study was to evaluate the antiglaucoma effect of calcium channel blockers diltiazem and verapamil. Albino rabbits were used and chronic glaucoma was induced in them using freshly prepared 150 units of alphachymotrypsin. 0.1 mL of drug solution was administered topically into the left eye whereas the right served as control. The pressure recording was carried out at 15, 30, ...

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61: Calcium Channel Blockers

In 1964, Albretch Fleckenstein described an inhibitory action ofverapamil and prenylamine on excitation-contraction coupling that was similar to calcium depletion. By the late 1970s, the clinical use of calcium channel blockers (CCBs) was widely accepted for variety of cardiovascular indications, including hypertension, dysrhythmias, and angina. Later indications, including Raynaud phenomenon, ...

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ژورنال

عنوان ژورنال: American Journal of Epidemiology

سال: 2012

ISSN: 1476-6256,0002-9262

DOI: 10.1093/aje/kwr362